Alzheimer's drug Leqembi: The twice-monthly infusion could be available in injection form

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Makers of the new Alzheimer's drug, Leqembi, say their twice-monthly infusion could be available in injection form at pharmacies by early 2025 — if all goes well in ongoing trials and the regulatory process.

Eisai and Biogen (BIIB), co-developers of the recently approved intravenous (IV) drug, announced new data Thursday that shows an injection under the skin could deliver about the same results as an infusion through IV. That could allow patients to switch to using the injection alone, if the data supports it long-term, or alternate between the two if the patient is comfortable with at-home injections.

The new data shows an increase in clearing beta-amyloid plaques in the brain — a controversial telltale sign of Alzheimer's that served as the basis of Leqembi's clinical trials — by 14% through injection compared to IV.

The injection option, analysts say, could increase the revenue potential for the drug. "Overall, we view this update as highly positive, and expect these results to raise expectations for Leqembi’s potential market penetration, as a (subcutaneous) formulation could ease the burden on patients and the healthcare system and accelerate uptake," Goldman Sachs analysts said Thursday.

While some investors continue to anticipate a slow initial launch, Eisai executive vice president Alex Scott told Yahoo Finance that uptake for the IV is actually going better than expected.

"The formulary approvals are happening at a faster clip than we had in our plans," he said.

MANHATTAN, NY - MAY 23, 2023 -  Hundreds of advocates from across New York, New Jersey, and Connecticut rally outside the Centers for Medicare and Medicaid Services (CMS) regional office in downtown Manhattan (Jacob Javitz Federal Building). They were asking CMS to reverse its decision and cover two FDA-approved Alzheimer's drugs, Leqembi and Aduhelm.  (Photo by Luiz C. Ribeiro for NY Daily News via Getty Images)
Hundreds of advocates rally outside the Centers for Medicare and Medicaid Services (CMS) regional office in Manhattan on May 23, 2023, asking CMS to reverse its decision and cover two FDA-approved Alzheimer's drugs, Leqembi and Aduhelm. (Luiz C. Ribeiro for NY Daily News via Getty Images) · New York Daily News via Getty Images

Removing barriers

In fact, the demand for the drug is creating new treatment models in places like Dallas, where one health system is putting a neurologist, infusion centers, and MRI monitoring all under one roof — three key elements needed to monitor patients in a timely manner rather than scheduling and coordinating separate visits for each step.

Meanwhile, companies are already vying for their piece of the business.

LabCorp (LH), for example, announced a blood-based test to help identify biomarkers that are signals of Alzheimer's, thereby identifying more potential patients for the drug. Another example is GE Healthcare (GEHC), which partnered with Eisai early on in the R&D process. It is lobbying for its PET, or imaging scans that can be used for the brain, to be used more than once during a patient's therapy journey.

Building new infusion sites is another way to get a share of the business — but it is a limiting factor in the eyes of investors.

"We are encouraged by these results and are positive on the commercial opportunity ... which would circumvent the need to build up infrastructure around infusion centers and greatly increase ease of administration," Leerink Partners analysts said in a note Thursday.